WORLD JOURNAL OF ADVANCE
HEALTHCARE RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Review Journal for Medical Science and Pharma Professionals

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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Indexing

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  • Google Scholar
  • Index Copernicus
  • SOCOLAR, China
  • Research Bible, Fuchu, Tokyo. JAPAN
  • Cosmos Impact Factor
  • Scientific Indexing Services (SIS)
  • UDLedge Science Citation Index
  • International Impact Factor Services
  • International Society for Research Activity (ISRA) Journal Impact Factor (JIF)
  • Scientific Journal Impact Factor (SJIF)
  • IFSIJ Measure of Journal Quality
  • International Scientific Indexing, UAE (ISI) (Under Process)
  • International Impact Factor Services (IIFS)
  • Web of Science Group (Under Process)
  • Directory of Research Journals Indexing
  • Scholar Article Journal Index (SAJI)
  • International Scientific Indexing ( ISI )
  • Academia
  • Scope Database
  • Research Publication Rating and Indexing
  • Doi-Digital Online Identifier
  • ISSN National Centre
  • Zenodo Indexing
  • International CODEN Service, USA

Abstract

THE EFFECTS OF A 6-MONTH ADHERENCE TO A VERY LOW CARBOHYDRATE DIET PROGRAM: A CLINICAL AND METABOLIC EVALUATION

Hisham Ibrahim Khalil, Omar Basheer Badran*, Firas Husam Ali

ABSTRACT

Background: Very low-carbohydrate diets (VLCDs) have emerged as an effective dietary strategy for weight loss and metabolic improvement; however, evidence regarding their medium-term safety and efficacy remains limited. Objective: This study evaluated the clinical and metabolic effects of a 6-month VLCD intervention in overweight and obese adults. Methods: A prospective cohort study was conducted with 60 participants (BMI ≥ 27 kg/m²) who adhered to a VLCD (≤50g of carbohydrates/day) over six months. Anthropometric, glycemic, and lipid parameters were assessed at baseline, 3 months, and 6 months. Data were analyzed using repeated-measures ANOVA with Bonferroni-adjusted post-hoc tests. Results: Significant reductions were observed in body weight (−9.3 ± 1.8 kg), BMI, waist circumference, fasting glucose, HbA1c, and triglycerides (p < 0.001), alongside a significant increase in HDL cholesterol (p < 0.01). No significant changes were detected in LDL cholesterol or markers of kidney or liver function. Conclusion: Six-month adherence to a VLCD resulted in clinically meaningful improvements in weight, glycemic control, and lipid profiles without adverse renal or hepatic effects, suggesting its efficacy and safety as a short- to mid-term dietary intervention for metabolic improvement.

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