WORLD JOURNAL OF ADVANCE
HEALTHCARE RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Review Journal for Medical Science and Pharma Professionals

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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  • Google Scholar
  • Index Copernicus
  • SOCOLAR, China
  • Research Bible, Fuchu, Tokyo. JAPAN
  • Cosmos Impact Factor
  • Scientific Indexing Services (SIS)
  • UDLedge Science Citation Index
  • International Impact Factor Services
  • International Society for Research Activity (ISRA) Journal Impact Factor (JIF)
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  • Scientific Journal Impact Factor (SJIF)
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Abstract

HLA POLYMORPHISM IN CANCER

Mohammad Abdaljabbar Ahmed*, Ghada Khairy Malik Khairy Al-hindawi, Rajaa Abed Ali, Saif Ali Mohammed Hussein

ABSTRACT

HLA is the gene cluster presents in chromosome no 6 in human. The Polymorphism in this gene leads to many abnormality and diseased condition due to variation in the HLA antigens those are responsible for the activation of immunological molecules and cells. In our study total genome was isolated from Normal and diseased blood and was tested for the variation in HLA gene at its major allelic sites. HLA-SSP PCR was performed in which HLA allele specific primers were used. This analysis resulted in the alleles that can cause cancer. The alleles were expressed B0702 and It was found that theses allele is also responsible for causing leukemia. The normal blood is amplified by using the marker primer DRB301 as control.

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