WORLD JOURNAL OF ADVANCE
HEALTHCARE RESEARCH

John E. Thoppil, S. Aneesh*

ABSTRACT

The species richness of mushrooms and their natural beauty has long fascinated mankind. We have treasured them for their medicinal and culinary properties. Microporus, a least explored bracket fungus belongs to the family polyporaceae under the class basidiomycetes. Fungal secondary metabolites have shown promising neuroprotective effects, offering potential therapeutic avenues for neurodegenerative diseases like Alzheimer’s and Parkinson’s. Neurodegeneration is mainly characterized by the accumulation of amyloid – β-peptide (Aβ). Since it is an important cause of neuronal death, there is a need for neuroprotective studies. Thus, neuroprotective activity of M. affinis and M. xanthopus was screened using IMR-32, neuroblastoma cell lines using MTT assay and apoptotic determination by using Acridine orange and ethidium bromide double staining method. Even though, M. xanthopus, is more potent in antiapoptotic properties, further validations are needed to support its neuroprotective efficacy.