WORLD JOURNAL OF ADVANCE
HEALTHCARE RESEARCH

Dr. Kulvinder Kochar Kaur*

ABSTRACT

Earlier we had detailed the association amongst abdominal obesity(AO), type2 diabetes mellitus( T2DM), Heart failure with preserved ejection fraction (HFpEF), role of adipose tissue (AT) impairment on liberation of adipocytokines, inclusive of adiponectin, leptin, resistin, visfatin, omentin, angiopoietin like protein, zinc—α-2glycoprotein, glypican 4, lipocalin 2, secreted frizzled – related protein(SFRP), retinol binding protein-4, TNFα, IL-6& IL-18,. Additionally, Diabetic cardiomyopathy (DbCM) represents a cardiovascular disease (CVD). Men & women having DM possessed 2. 4 &5 fold greater incidence of HF respectively. Patients of DM possessed greater prevalence of HF with variation from 19-26%.[3] Furthermore, role of epigenetics inclusive of DNA methylation;, histone post-translational modifications, histone acetylation, miRNAs circRNA, lnc RNAs histone HDAC1-6; cardiac remodelling, cardiac fibrosis, cardiac hypertrophy, LV hypertrophy, modes of cell demise likecardiomyocytes apoptosis, autophagy, pyroptosis and PI3K&other various signalling pathways. Recently we further updated therapy inclusive of Sodium Glucose Transporter 2 SGLT hampering agents, glucagon like peptide 1(GLP-1)-1 receptor agonist(GLP-1RA), as innovative mechanistic modes for the avoidance of HFpEF by utilization of GLP-1RA in case of patients with obesity, or metabolic syndrome(MetS) or obese diabetic patients particularly tackling the sequelae of obesity on the heart in addition to on HFpEF, the countercontrolling Renin-Angiotensin system(RAS) andavoidance of cardiovascular injury in such a backdrop. Lastly, GLP-1 axis is detailed asanti diabetic, anti obesity along with anti cardiac remodeling pathway. Moreover, previously we have outlined part of escalated TG’s and diminished HDL-C in the formation of IR as well as MetS, emphasized significance triglyceride-glucose (TyG) indices for instance triglyceride-glucose body mass index (TyG-BMI) ], triglyceride-glucose waist circumference (TyG-WC) &triglyceride-glucose waistto-height ratio (KeyWords; TyG-WHtR) marker for evaluating IR in contrast to the euglycemic-hyperinsulinaemic clamp test. Here we further detail how TyG might be a meaningful anticipator of HFpEF prognosis in this short communication’’.