WORLD JOURNAL OF ADVANCE
HEALTHCARE RESEARCH

Sedra Abd Alhamid Jiffi Bahloul*, Mohammad Imad Khayyat, Nader Abdullah

ABSTRACT

Background: Evaluation of the prognostic role of LDH levels In patients with metastatic NSCLC and its role In the response for chemical treatment. Methods: The study concluded 75 patients who were conducted to the Oncology Center at Latakia University Hospital between 2023-2024, who were diagnosed with metastatic NSCLC. A detailed medical history was taken with CT scan and histological study results. LDH values were calibrated before and after treatment In the same way. Results: The total sample of the study was 75 patients, including (72%) males and (28%) females, with a probability for the age group of 56-65 years, the percentage of smokers in the study sample was 72%. Adenocarcinoma ADC was the most common histological type (60 patients), followed by squamous cell carcinoma (15 patients). When studying the relationship between LDH levels and the histological type of tumor, there were no statistically significant differences (p-value>0.05). The average LDH values were directly proportional to the progression of the brain metastasis in the study patients, with a statistically significant difference (p-value<0.05). Conclusion: LDH is a predictive marker In patients with metastatic NSCLC and helps In assessing response and prognosis In patients. In addition, assessment of their response for treatment.