News & Updation
Best Paper Awards
World Journal of Advance Healthcare Research (WJAHR)Honored the authors with best paper award, monthly based on the innovation of research work. Best paper will be selected by our expert panel.
Best Article of current issue
Download Article : Click here
SPECTRUM OF ANTIRETROVIRAL (ART) REGIMEN CHANGE AND CONTRIBUTING FACTOR AMONG ADULT HIV/AIDS PATIENT AT SHAMBU HOSPITAL, SHAMBU TOWN, HORRO GUDURU WOLLEGA ZONE, OROMIA REGIONAL STATE, ETHIOPIA
Background: Human Immune Virus (HIV) is responsible for a worldwide pandemic and it is the cause of Acquired Immune Deficiency Syndrome (AIDS). According to latest statistics 33.4 million individuals worldwide are living with HIV, of which 15.7 million (47%) are women and 2.1 million (6.3%) are children under 15 years. In addition there are 2.7 million new infections and 2.0 million deaths from AIDS worldwide. Result and Conclusion: Patients that changed their regimen were included in the study to identify the reasons for change and descriptive statistics were generated by Using SPSS & using excels for figures. Out of patients, % were females and % were in the age group -. % were WHO clinical stage III patients and % of patients had missed their CD4 count. In % of patients initial treatment regimen was modified after six months, while, in % and % of patient’s initial regimen was modified less than a month and within two to three month time respectively, the most common initial regimens were D4T/3TC/NVP (%), AZT/3TC/NVP (%) and D4T/3TC/EFV (%) The main reasons for modification of therapy were toxicity (%), new drug (%), treatment failure (%), new TB (%), stock out (%), and pregnancy (%) respectively. The main toxicity observed was peripheral neuropathy (%) followed by rash (%) and anemia (%). Among toxicities observed % were due to D4T/3TC/NVP, and the remaining %, %, %, %, % and % were due to AZT/3TC/NVP, D4T/3TC/EFV, AZT/3TC/EFV, TDF/3TC/EFV, TDF/3TC/NVP, and TDF/3TC/LPVr respectively. D4T containing regimens accounted for % of the peripheral neuropathy observed, while NVP containing regimens accounted for % of the rashes reported and AZT containing regimens accounted for % of the Anemia observed. Toxicity was the main reason for initial regimen modification, D4T based regimens had high incidence of peripheral neuropathy. Objective: To determine the reason and contributing factors of anti-retroviral regimen changes among patients on anti-retroviral therapy in ART clinic of Shambu Hospital. Method: A retrospective cross-sectional study was done using patient information sheet and physician diagnosis card from January 1, 2008 to December 31, 2016.[Full Text Article]