WORLD JOURNAL OF ADVANCE
HEALTHCARE RESEARCH

Yash Srivastav, B. V. B. Balaji, Neha Yadav, Shankar Gavaroji, Shivanand Gavaroji, Aaliya Naaz,
Shubham Sagar, Sujit Borey and Anil Kumar*

ABSTRACT

Background: Sudden cardiac arrest (SCA) has notably increased in incidence following the COVID-19pandemic. The intersection of SARS-CoV-2 infection with metabolic syndrome (MetS), lifestyle changes duringthe pandemic, and complex pathophysiological mechanisms contributes to this surge. Objective: This reviewaims to synthesize current evidence on the role of metabolic syndrome and lifestyle risk factors in post-COVID-19SCA, explore emerging pathophysiological insights, and discuss prevention and management strategies.Methods: A comprehensive literature review was conducted, focusing on epidemiological data, mechanisticstudies, and clinical reports related to COVID-19, metabolic syndrome, and SCA. Results: SARS-CoV-2 inducescardiovascular injury through inflammation, endothelial dysfunction, and autonomic imbalance. Metabolicsyndrome components—hypertension, dyslipidemia, insulin resistance, and central obesity—exacerbate theseeffects. Pandemic-associated sedentary behavior, poor diet, and mental health stressors further elevatecardiovascular risk. Emerging research employing omics and AI techniques offers promise for improved riskstratification and targeted therapies. Conclusion: The post-COVID-19 rise in SCA necessitates integratedmultidisciplinary approaches encompassing metabolic control, lifestyle modification, vigilant cardiovascularscreening, and public health interventions. Continued research is essential to mitigate long-term cardiovascularsequelae.