WORLD JOURNAL OF ADVANCE
HEALTHCARE RESEARCH

*Zubair Aziz Gerdo and Saad Hussein Hammo

ABSTRACT

Background: Asthma is a chronic lung immunological disease that causes reversible airway narrowing,inflammation, and hyperresponsiveness to triggers. It is a widespread chronic, noncommunicable conditionaffecting both children and adults. Vitamin D insufficiency is linked to exacerbations, poor control of symptomsand increased inflammatory respond in pediatric asthma. Objectives: To assess the independent serum vitamin Dlevels in asthmatic children, as well as the link between vitamin D and asthma severity. Methods: This is a casecontrolstudy was carried out from August 2023 to December 2024 in the pediatric department at Talafar andMosul General Hospital in Nineveh. Patients (2–14 years old) who had recurrent coughing, dyspnea, wheezing,and bronchodilator-reversible symptoms were recruited as asthma patients (cases). Compared with age- andgender-matched children who had never had asthma and attended the same setting (controls). The questionnaireincluded four parts, part one for socio-demographic information of the study participants, part two for the patient’sclinical presentation and asthma severity, part three for Vitamin D level and triggers affecting Vitamin level.Results: The study includes 100 patients, 50 of them had asthma and considered the cases and matched with 50patients never had asthma and considered as controls. The mean age of the study participants is 8.02 ± 1.39 years.It’s evident that presence of positive family history of bronchial asthma within the cases is statistically significantdifference than in controls (P value <0.001). Moreover; statistically significant difference is found between thecases and controls regarding their Vitamin D levels (P value <0.001). Furthermore; statistically significantdifference between types of asthma regarding their Vitamin D levels. (P value <0.001). No statistically significantdifference found between the level of asthma control, treatment that may affect Vitamin D and the presence ofpassive smoking with regard to Vitamin level (P value >0.05). Conclusion: Vitamin D deficiency andinsufficiency are closely linked to childhood asthma, but it has no meaningful impact on illness severity orcontrol. Children with asthma showed decreased serum vitamin-D levels compared to age- and gender-matched,healthy controls.