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Abstract
URIC ACID - CREATININE RATIO IN PATIENTS WITH RENAL STONES
Dr. Navanil Roy and Dr. Mrinal Gupta*
ABSTRACT
The prevalence of kidney stone disease in India is 11%. Adult males are 3 times more affected than females and is a major cause of morbidity in human beings. The metabolic defects are less common cause in the patient presenting for the first time with kidney stones than the recurrent stone formers. The present study was aimed to determine the urinary levels of uric acid and creatinine. Uric acid and creatinine ratio were determined to assess the susceptibility for stone formation in such patients. In our research work we took 30 clinically diagnosed cases of urolithiasis and 30 age and sex matched healthy controls. Our results showed increased concentration of stone promoters such as uric acid and decreased concentration of stone inhibitors such as creatinine in urine of urolithiasis patients. Observations of our research work provide some evidence regarding the role of the above-mentioned ratios in the pathogenesis as well as susceptibility of such subjects for urolithiasis.
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