WORLD JOURNAL OF ADVANCE
HEALTHCARE RESEARCH

*Dr. Hasan Shihab Ahmed Alsobaihi Dr. Rawaa Jasim Ahmed Matloob, Dr. Abdulrahman Saad M Shawkat Sulaiman and Dr. Mudheher Ibrahim Salih

ABSTRACT

Background:With a global frequency of 21%, functional dyspepsia (FD) is a recurrent and remitting illness thataffects the gastro duodenal tract. Post prandial discomfort (PDS) and epigastric pain syndrome (EPS) are its twosubtypes. Gastric dysfunction, acid hypersensitivity, Helicobacter pylori infection, dysregulation of the gut brainaxis, and hereditary variables are some of the multimodal pathogenesis. Aim of study: To evaluate the effect ofPPI overuse on gast ric motility and functions. Methodology: A clinical trial study was conducted from January2024 till May 2024 in endoscopic unit in Al Mosul General Hospital, database surveyed 120 patients, whocomplain from upper GI symptoms (epigastric pain, bloating, e arly satiety, nausea, burning) who tried to used PPIfor long period undergoing Oesophageo Gastro Duodenoscopy (OGD) and send stool for H.pylori and urea breathtest. Results: The study compared 69 patients and 41 controls, with males being the predominant group. The mostcommon age group was 20 25 years, while the least common was ≥75 years. There were no significant differencesin age, sex, occupation, marital status, smoking, or family history. The duration of the disease was 2 5 years for 35patients an d 1 2 years for 5 controls. Symptoms included epigastric pain, retrosternal pain, and regurgitation. Mostcases and controls showed Gastritis, while 10.1% and 2.4% showed Gastritis. Positive H. pylori tests were foundin 39.1% of cases and 31.7% of control s. Conclusion: When compared to a placebo, there is proof that PPIs arebeneficial in treating FD, regardless of dosage or length of treatment. With no or no short term adverse effects,PPIs may have an analgesic impact in acute pain disorders such epigastric and non chest thoracic discomfort ofupper digestive system origins.