WORLD JOURNAL OF ADVANCE
HEALTHCARE RESEARCH

Ahmed Mudher Al- Khaykanee* and Soura Alaa Hussein

ABSTRACT

Background: XRCC1 gene polymorphisms have been associated with hepatocellular carcinoma HCC, lung cancer, pancreatic cancer, and breast cancer. This study aims to examine the association between XRCC1 rs139599857 and rs2293035 polymorphisms and breast cancer. Methods: 100 samples were taken from BC patients and healthy individuals. The genotype of the XRCC1 rs (139599857) and ( rs2293035) employing allele-specific real-time PCR to identify the samples. Result: XRCC1 rs139599857 The genotypes GC and CC were substantially correlated with an elevated risk of BC [OR = 2.98 (2.07 – 7.22), P < 0.001 and OR = 3.11 (0.59 – 9.11), P < 0.001, correspondingly]. Comparable results were noted at the allele level, with carriers of the C allele exhibiting an elevated risk for developing BC [OR = 2.41 (1.64 – 4.01), p< 0.001].The XRCC1 C/T variant genotypes CT and TT were strongly correlated with an elevated risk of BC, with [OR = 3.21 : 2.21 –8.11, P < 0.001) and 3.23 (OR: 1.11 – 7.87, P < 0.001), correspondingly]. Comparable results were noted at the allele level, with carriers of the T allele exhibiting an elevated risk for developing BC [OR = 3.46 (1.53 – 2.88), p < 0.001]. Conclusion: In conclusion, XRCC1rs 139599857 the GC genotype and G allele and XRCC1 rs 1395998570 and CT genotype and T allele connected to a higher risk of BC.