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Abstract
TESTOSTERONE SCREENING IN POSTOPERATIVE IRAQI ACROMEGALY MALE PATIENTS WITH AND WITHOUT DIABETES
Lujain A. Ghannawi*, Omar Yasir Shakir, Jihad Anad Khalaf, Karam Gharab, Haidar Fadhil Al-Rubay’e, Mohamed A. Thamer
ABSTRACT
Acromegaly is a syndrome, that results from excessive pituitary growth hormone (GH) secretion, leading to increased insulin-like growth factor-1 (IGF-1) production, usually due to a pituitary adenoma. Acromegaly often leads to disruptions in hormone levels, including testosterone. Blood testosterone levels are crucial in assessing hypogonadism in these patients moreover; the diabetes may further complicate this imbalance. 120 samples were enrolled in this study (Acromegalic male and healthy control) aged from 30 to 60 years old, collected and grouped into three groups, the first 40 patients were with diabetes, and the other 40 patients were without diabetes. At the same time, the healthy controls were 40 participants. GH, IGF-1, FBS, and testosterone levels were measured for all study groups. Results showed significant differences between acromegaly patients and control in the study parameters, p-value (< 0.05). While, between diabetic and non-diabetic acromegaly only testosterone levels show significant differences (p-value=0.000). As a conclusion, high GH and IGF-1 levels disrupt the HPG axis, leading to hypogonadism and lower testosterone levels, which are linked to erectile dysfunction. Additionally, testosterone levels were significantly lower in acromegaly patients with diabetes compared to non-diabetic acromegaly patients, highlighting the negative impact of diabetes on testosterone production. These hormonal disruptions contribute to common symptoms like reduced libido and fatigue in affected men.
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