WORLD JOURNAL OF ADVANCE
HEALTHCARE RESEARCH

Azher Abbas Naser, Salam Naser Zangana, *Iman Jabbar Kadhim, Falah Abdulhasan Deli and Wijdan Rajh Hamza Al-Kraity

ABSTRACT

Background: Increasing value of Red cell distribution width (RDW) is documented to be linked to worse clinical outcomes so that it can be considered as a prognostic indicator in states like acute myocardial infarction coupled with other inflammatory markers taking in consideration its easy availability. Aim of the study: This study aimed to assess the relationship of RDW and echocardiographic parameters especially systolic and diastolic dysfunction in patients with ST-elevation myocardial infarction (STEMI). Patients and methods: In this study 60 {38 (63%) were males and 22 (37%) females} consecutive patients who had acute ST elevation myocardial infarction (STEMI) at Rozhalat hospital, Erbil, Iraq were included, RDW was obtained during the event of STEMI and the levels obtained where analyzed according to measures of systolic and diastolic dysfunction calculated by transthoracic echocardiophic study. Results: RDW was found to be increasing in patients with impaired systolic and diastolic functions (ejection fraction of the left ventricle <50%, diastolic filling wave (E/A)<1 , peak early transmitral velocity over early diastolic annular velocity [E/E'] >10 , and more obviously with combined E/A < 1 and E/E' > 10 (P <0.01). The best cut off value of RDW was 13% with sensitivity (75.9%) and specificity (61.3%) and this is obtained applying ROC curve analysis according to echocardiography ejection fraction 50%. Conclusion: Elevated RDW can be considered as a new biomarker of poor outcome in patients acute STEMI patients as it is associated with diastolic as well as and to a lesser extent systolic dysfunction in patients with STEMI even after adjustment of several confounding factors.

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