WORLD JOURNAL OF ADVANCE
HEALTHCARE RESEARCH

*Jihan Jasim Kadhim, Munib Ahmed Al-Zubaidi and Abeer Degan Abdul-Amir

ABSTRACT

Background: Diabetics' first indicator of nephropathy is microalbuminuria. Early identification of microalbuminuria in diabetics is essential for preventing and treating diabetic nephropathy. The aim of this study was to examine the relationship between glomerular filtration rate (GFR) and urine albumin excretion in children with type 1 diabetes (T1DM) and its importance in detection of diabetic nephropathy. Method: This cross-sectional study was conducted at the emergency and diabetes clinics of Children Welfare Teaching Hospital-Medical City/Baghdad from February 1 to August 31, 2023. In a study of 123 children with T1DM, 75 were female and 48 were male. They ranged in age from 5-13.5, with a duration of diabetes from 2-11 years. Patients were admitted with RBS >300 mg/dl and had blood samples taken for serum creatinine and RBS testing. GFR was estimated using Schwartz formula in all patients. Urine from the first morning was tested for albumin: creatinine ratio. A paired sample T test and 0.05 statistical significance were used to analyses data. Results: In this study, 26 (21.1%) patients with DM more than five years had positive urine spots (17 females and 9 male), two (7.6%) had macro albuminuria, and 90 (73.1%) had negative results. Microalbuminuria was associated with poor glycemic control (p: 0.009), but not with diabetes duration (p: 0.182), urine spot, age (P: 0.278), sex (P: 0.860), or S. creatinine (P: 0.095). Microalbuminuria was associated with glomerular hyper filtration (p: 0.013). Conclusion: Urine albumin-to-creatinine ratio increases with glomerular hyper filtration. Poor glycemic management may cause early diabetic nephropathy regardless of duration.

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