WORLD JOURNAL OF ADVANCE
HEALTHCARE RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Review Journal for Medical Science and Pharma Professionals

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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  • Google Scholar
  • Index Copernicus
  • SOCOLAR, China
  • Research Bible, Fuchu, Tokyo. JAPAN
  • Cosmos Impact Factor
  • Scientific Indexing Services (SIS)
  • UDLedge Science Citation Index
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Abstract

BIOCHEMICAL PREDICTORS OF NEPHROPATHY IN ADOLESCENTS WITH TYPE 1 DIABETES MELLITUS

*Abeer Degan Abdul-Amir, Hanaa Ali Abduljabbar and Jihan Jasim Kadhim

ABSTRACT

Background: Diabetic nephropathy is the leading cause of end-stage renal disease. Inflammation and endothelial dysfunction are key factors in its onset and progression. Aim: To investigate the correlation between serum uric acid, insulin-like growth factor binding protein 1 (IGFBP1), and albuminuria as early predictors of nephropathy in adolescents with type 1 diabetes mellitus. Methods: A cross-sectional study was conducted at Children Welfare Teaching Hospital, Baghdad, from January to July 2023. It included 88 adolescents (aged 11-15 years) with type 1 diabetes: 44 newly diagnosed (Group 1) and 44 with poorly controlled diabetes for over three years (Group 2). Clinical examinations, urine albumin-to-creatinine ratio, serum uric acid, and fasting IGFBP1 were assessed. Results: Group 1 and Group 2 each constituted 50% of the participants, with mean ages of 12.5±0.7 and 13.2±0.7 years, respectively. In Group 2, 19 (43.18%) patients had albuminuria (15 with microalbuminuria and 4 with macroalbuminuria). Serum IGFBP1 and uric acid levels were significantly higher in Group 2 than Group 1 (p=0.006 and p=0.000, respectively). Within Group 2, uric acid was significantly elevated in those with nephropathy (p=0.000), but IGFBP1 showed no significant difference (p=0.434). IGFBP1 levels were significantly higher in Group 2 without albuminuria compared to Group 1 (p=0.001). Conclusion: Elevated serum uric acid and IGFBP1 are associated with nephropathy development in type 1 diabetes. IGFBP1 can serve as an early biomarker for predicting nephropathy before the onset of albuminuria.

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