WORLD JOURNAL OF ADVANCE
HEALTHCARE RESEARCH

*Nisa Uyar Alpaslan, İ. Ömer Barlas and Ayse Devrim Basterzi

ABSTRACT

Background and objectives: Bipolar disorder (BP) is a heterogeneous disease, with genetic factors being important in its etiology. Although many target genes associated with BP have been studied to date, little is known about the genetic background of the disease. Myo-inositol monophosphatase (IMPAse), encoded by the myo-inositol monophosphatase 2 (IMPA2) gene, plays a role in the phosphatidylinositol 4,5-biphosphate (PIP2) signaling pathway. IMPase is a key enzyme which catalyzes the dephosphorylation of myo-inositol monophosphate to free myo-inositol. This reduction slows down signal transduction in the PIP2 cycle, leading to an increase in inositol monophosphate levels. We examined the relationship between IMPA2 gene polymorphisms and BP. Methods: The study included 94 individuals with a diagnosis of BP and 99 healthy individuals. Molecular analysis of the IMPA2 gene of each individual was performed by real-time polymerase chain reaction (real-time PCR). Results: There was an association between the IMPA2 gene rs650727 polymorphism and patients with BP (p = 0.038). By contrast, no association was found between IMPA2 gene polymorphisms rs1787984, rs585247, rs669838, and rs636173 and BP. Conclusions: Our results showed that there was a possible association between polymorphism rs650727 in IMPA2 and BP. This represented the first study of IMPA2 gene polymorphisms and BP in a Turkish population.