WORLD JOURNAL OF ADVANCE
HEALTHCARE RESEARCH

Senthil Prabhu R.*, Balaji S., Govindhan A., Suresh M. and Sathiyarasu S.

ABSTRACT

Proniosomes is an advanced vesicular drug delivery system that have emerged as a versatile solution for controlled and targeted drug release across various administration routes. As a precursor to niosomes, proniosomes are comprised of non-ionic surfactants and cholesterol, which enhance their ability to encapsulate a wide range of drug types, from hydrophilic to lipophilic compounds, making them highly adaptable across multiple routes of administration offering advantages in storage stability and ease of handling. This review delves into various methods of proniosome preparation—such as the slurry, coacervation-phase separation, and spray-coating methods—each of which enables formulation scalability and ensures consistency in drug delivery. Characterization techniques, including scanning electron microscopy, particle size analysis, and encapsulation efficiency assessment, further emphasize the robustness and versatility of proniosome-based system. Compared to traditional vesicular systems like liposomes, proniosomes present enhanced stability, bioavailability, and compatibility with both hydrophilic and lipophilic drugs, making them suitable for oral, topical, transdermal, ocular, pulmonary, and peptide delivery applications. Additionally, proniosomes overcome limitations such as aggregation, leakage, and short circulation times, providing a reliable drug delivery platform with potential in treating various diseases and improving therapeutic outcomes. The adaptability of proniosome formulations and their reduced toxicity highlight their promising role in advancing targeted drug delivery systems.

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