Login
News & Updation
Best Article Awards
World Journal of Advance Healthcare Research (WJAHR) is giving Best Article Award in every Issue for Best Article and Issue Certificate of Appreciation to the Authors to promote research activity of scholar.
Best Article of current issue
Download Article : Click here
Indexing
Abstract
BIOCHEMICAL PATHWAYS IN CANCER METABOLISM: IMPLICATIONS FOR THERAPEUTIC TARGETING
Sarmad Falih Mohammed*, Athraa H. Ibrahim and Alaa R. M. Chyad
ABSTRACT
Our distinct metabolic reprogramming of cancer cells supports their rapid growth and survival. In this review, we focus on the metabolic pathway alterations that include glycolysis, tricarboxylic acid (TCA) cycle, lipid metabolism, and amino acid metabolism which define tumor development. With advances in metabolic imaging and biomarkers, we know better what goes wrong and are able to detect and monitor cancer earlier. Discussion of current and emerging therapeutic approaches to target metabolic vulnerabilities, including inhibitors of glycolysis, glutaminolysis, fatty acid synthesis and IDH mutations, is included. Redox modulation and immunometabolism also present promising avenues for personalized cancer therapy, these strategies along with the others. Our strategy takes advantage of the inherent metabolic differences between normal and tumor cells to develop more effective interventions than before, aimed at improving patient outcomes.
[Full Text Article] [Download Certificate]