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Abstract
NO ASSOCIATION OF THE LEPTIN (RS17151919) AND LEPTIN RECEPTOR (RS3790434) GENE POLYMORPHISMS WITH IRRITABLE BOWEL SYNDROME IN TURKISH POPULATION
Kenan CEVIK*, Mustafa Ertan Ay, Fehmi Ates, Ozlem Izci Ay, Umit Karakas and Mehmet Emin Erdal
ABSTRACT
Background: Irritable bowel syndrome(IBS) is a gastrointestinal(GI) system disease that is characterized by altered bowel habits and abdominal pain in the absence of detectable structural abnormalities. Familial aggregation and twin studies suggest that there is a genetic contribution to the development of disease. Leptin and its receptors expressed in gastric mucosa and present in the GI system, especially in the proximal intestine, have complex effects on GI tract motility, nutrient absorption, and immune modulation of the GI system. Material and methods: leptin (rs17151919) and leptin receptor (rs3790434) polymorphisms were investigated in 159 patients with IBS and 104 healthy subjects in Turkish population using Real-time PCR. Results: Current findings display that there was no significant difference in leptin and leptin receptor genotype distribution or allele frequency between the patient and control groups. Conclusion: Our results indicate that leptin and leptin receptor gene polymorphisms may not be genetic risk factors for IBS development in a sample of Turkish population.
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