WORLD JOURNAL OF ADVANCE
HEALTHCARE RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Review Journal for Medical Science and Pharma Professionals

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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  • Index Copernicus
  • SOCOLAR, China
  • Research Bible, Fuchu, Tokyo. JAPAN
  • Cosmos Impact Factor
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Abstract

NO ASSOCIATION OF THE LEPTIN (RS17151919) AND LEPTIN RECEPTOR (RS3790434) GENE POLYMORPHISMS WITH IRRITABLE BOWEL SYNDROME IN TURKISH POPULATION

Kenan CEVIK*, Mustafa Ertan Ay, Fehmi Ates, Ozlem Izci Ay, Umit Karakas and Mehmet Emin Erdal

ABSTRACT

Background: Irritable bowel syndrome(IBS) is a gastrointestinal(GI) system disease that is characterized by altered bowel habits and abdominal pain in the absence of detectable structural abnormalities. Familial aggregation and twin studies suggest that there is a genetic contribution to the development of disease. Leptin and its receptors expressed in gastric mucosa and present in the GI system, especially in the proximal intestine, have complex effects on GI tract motility, nutrient absorption, and immune modulation of the GI system. Material and methods: leptin (rs17151919) and leptin receptor (rs3790434) polymorphisms were investigated in 159 patients with IBS and 104 healthy subjects in Turkish population using Real-time PCR. Results: Current findings display that there was no significant difference in leptin and leptin receptor genotype distribution or allele frequency between the patient and control groups. Conclusion: Our results indicate that leptin and leptin receptor gene polymorphisms may not be genetic risk factors for IBS development in a sample of Turkish population.

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