WORLD JOURNAL OF ADVANCE
HEALTHCARE RESEARCH

*Nourhan T. Younis, Emad Y. Mohammed and Allya Mohammed Ali

ABSTRACT

Background: Precocious puberty is characterized by early secondary sexual characteristics appearance, which are an early sign of pubertal development. Precocious puberty has two main underlying mechanisms: The first mechanism is gonadotropin dependent (central or true) precocious puberty, which occurs when there is early activation of the hypothalamic-pituitary-gonadal (HPG) axis. and the second method involves increased synthesis of sex hormones, without the need for hypothalamic-pituitary axis activation. Objectives: To determine the clinical spectrum and underlying aetiologies of children presented with precocious puberty at Al Khansa’a endocrine center in Mosul. Methods: An observational, descriptive, cross- sectional study. All patients with precious puberty who attend endocrine consultation unit of Al-Khansa’a Teaching Hospital between 10th of May 2019 to the end of June 2024 had been included. The Questionnaire was composed of two parts, the first included demographic information of the patients and the second the patient investigations, the third part include the final diagnosis. Results: The study includes 65 subjects with precocious puberty, 56 (86.2%) are females while 9 (13.8%) are males. With female to male ratio is 6.2:1. The mean age of the study population is 5.76 years, moreover; the mean age of females is 5.50 years and the mean age for males is 7.24 years. Idiopathic central precocious puberty is prevalent among 31 patients (30 females and 1 male) while neuropathic central precocious puberty is prevalent among 7 patients (6 females and 1 male). Moreover; with regards to peripheral precocious puberty; congenital adrenal hyperplasia (CAH) is prevalent among 19 patients (12 females and 7 males), Dehydroepiandrosterone increase, ovarian cyst and adrenal tumour are prevalent among 6, 1 and 1 female respectively. females are having more central causes of precocious puberty, normal height, weight, less tanner stage and more normal bone age at time of presentation versus male are showed more peripheral causes of precocious puberty, taller, thicker, more tanner stage and more advanced bone age at time of presentation. Conclusion: Precocious puberty affects females more than males, the commonest cause of central precocious puberty is idiopathic, while congenital adrenal hyperplasia is the commonest cause of peripheral precocious puberty. Precocious puberty is linked mostly with advanced bone age.

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