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Abstract
FORMULATION DEVELOPMENT & EVALUATION OF MEFENAMIC ACID EMULGEL FOR TOPICAL DELIVERY
Sangeeta Badatya*, Reena Shinde and Satkar Prasad
ABSTRACT
Topical drug delivery is the “process of applying a medication-containing formulation to the skin to treat a cutaneous ailment.” The application of topical treatments like ointments, creams, and lotions is uncomfortable for the patient since they are typically very sticky. They must be utilized carefully because they have a reduced spreading coefficient. They struggle with stability as well. To solve this issue, transparent gels have grown in popularity in cosmetic and pharmaceutical formulations. The formation of gels results from the considerable entrapment of an aqueous or hydroalcoholic liquid in a system of colloidal solid particles. Gel compositions offer a quicker therapeutic release than ointments and creams. Gels have one fundamental disadvantage despite all of their benefits: they cannot deliver hydrophobic medications. To get over this restriction, an emulsion-based technique is being created that will efficiently incorporate and deliver a hydrophobic therapeutic component across gels. Emulgels are dosage forms that combine the benefits of gels and emulsions. Emulsions have a refined appearance and can be readily removed from the skin. They also penetrate the skin fairly well. “Emollient, non-staining, water-soluble, easier spreadability, longer shelf life, bio-friendly, translucent, and a pleasing look are just a few of the benefits of emulgels for dermatological treatment.
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