WORLD JOURNAL OF ADVANCE
HEALTHCARE RESEARCH

Hadbi Mohamed*, Matouk Mohamed, Boutrid Hala, Benamane Raouf and Fellah Nadia

ABSTRACT

Purpose: To assess the efficacy and safety of intravenous tranexamic acid in reducing blood loss during and after elective cesarean section in parturients at high risk for postpartum hemorrhage. Methods: We carried out a double-blind, randomized controlled trial involving 800 parturients at high risk of PPH scheduled for cesarean section. They were randomly assigned to receive 1 g of tranexamic acid or placebo 15 min before the surgical incision. The assessment of intraoperative and postoperative blood loss was based on the volumetric and gravimetric methods. The statistical software SPSS version 20 was used for the analysis. Results: Our results showed that tranexamic acid significantly reduced bleeding during and after cesarean delivery. The total blood loss in the study group (299 ± 113 ml) was significantly lower than that in the placebo group (503 ± 246 ml) (p < 0.001). The mean decrease in hemoglobin level was significantly lower in the tranexamic acid group than in the control group (P= 0.0002). It also reduced the incidence of PPH (p = 0.0001), the need for blood transfusion (p = 0.04), and additional uterotonic use (p = 0.0007) without major adverse effects. Conclusion: Preoperative administration of TXA is effective in reducing intraoperative and postoperative blood loss during high-risk cesarean section, without major side effects. This provides a potential intervention for improving maternal outcomes.

[Full Text Article] [Download Certificate]