News & Updation
Best Paper Awards
World Journal of Advance Healthcare Research (WJAHR)Honored the authors with best paper award, monthly based on the innovation of research work. Best paper will be selected by our expert panel.
Best Article of current issue
Download Article : Click here
ANTIHYPERLIPIDEMIC ACTIVITY OF OILS EXTRACTED FROM TWO SUDANESE NILE FISHES IN CHOLESTEROL DIET-INDUCED HYPERLIPIDEMIC RATS
Nagwa Adam Abdulrhman Mohammed, Hatil Hashim EL-Kamali* and Amna EL-Hassan Hamad
The aim of the present research study was to investigate the possible antihyperlipidemic activity of fish oils obtained from two Nile fishes: Bagrous bagrous and Bagrous docmc in cholesterol diet-induced hyperlipidemia in albino rats. Treatment with B.bagrous “Bayad” fish oil at (1000, 500 and 250mg/kg b. w) showed significant (p<0.05) change in low density lipoprotein cholesterol (LDL-C), very low density lipoprotein cholesterol (VLDL-C) and triglyceride (TG) level, in addition , total cholesterol(TC) at (500mg/mg b. w), in 28 days treatment when compared to the control group (GP A).Treatment with B. docmac “Kaparose” fish oil at (1000,500 and 250mg/kg b. w) showed significant change (P<0.05) in all investigated lipid parameters (except TC at a dose of 250 mg /kg b. w), in 28 days treatment when compared to the control group (GP A). In hyperlipidemic activity rats treated cholesterol diet (GP B), a significant increase in serum cholesterol, LDL-C, VLDL-C and TG was observed on 28th days, when compared to normal rats (GP A). This shows that administration of cholesterol diet induced hyperlipidemia in the present study. .Group C receiving standard drug (Atorvastatin, 0.18 mg/kg b. w) and group D to group K receiving fish oils from “Bayad” and “Kaparose” 1000 mg/kg b. w, 500 mg/kg b. w, respectively showed a significant reduction in TC, LDL, VLDL and TG on 28th days in GP F(rats treated with 250 mg/kg b. w”Bayad” fish oil) , while showed a significant reduction in TC and LDL in GP K(rats treated with 250 mg/kg b. w ”Kaparose” fish oil) when compared to cholesterol group(GP B).Group F (rats treated with 250 mg/kg b. w “Bayad “ fish oil) showed a significant (P<0.05) reduction in TC, VLDL and TG on 28th days , while group K(rats treated with 250 mg/kg b. w “Kaparose” fish oil) showed a significand (P<0.05) reduction in TC when compared to standard drug(Atorvastatin).[Full Text Article]