WORLD JOURNAL OF ADVANCE
HEALTHCARE RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Review Journal for Medical Science and Pharma Professionals
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Indexing

Abstract

ANTIHYPERLIPIDEMIC ACTIVITY OF OILS EXTRACTED FROM TWO SUDANESE NILE FISHES IN CHOLESTEROL DIET-INDUCED HYPERLIPIDEMIC RATS

Nagwa Adam Abdulrhman Mohammed, Hatil Hashim EL-Kamali* and Amna EL-Hassan Hamad

ABSTRACT

The aim of the present research study was to investigate the possible antihyperlipidemic activity of fish oils obtained from two Nile fishes: Bagrous bagrous and Bagrous docmc in cholesterol diet-induced hyperlipidemia in albino rats. Treatment with B.bagrous “Bayad” fish oil at (1000, 500 and 250mg/kg b. w) showed significant (p<0.05) change in low density lipoprotein cholesterol (LDL-C), very low density lipoprotein cholesterol (VLDL-C) and triglyceride (TG) level, in addition , total cholesterol(TC) at (500mg/mg b. w), in 28 days treatment when compared to the control group (GP A).Treatment with B. docmac “Kaparose” fish oil at (1000,500 and 250mg/kg b. w) showed significant change (P<0.05) in all investigated lipid parameters (except TC at a dose of 250 mg /kg b. w), in 28 days treatment when compared to the control group (GP A). In hyperlipidemic activity rats treated cholesterol diet (GP B), a significant increase in serum cholesterol, LDL-C, VLDL-C and TG was observed on 28th days, when compared to normal rats (GP A). This shows that administration of cholesterol diet induced hyperlipidemia in the present study. .Group C receiving standard drug (Atorvastatin, 0.18 mg/kg b. w) and group D to group K receiving fish oils from “Bayad” and “Kaparose” 1000 mg/kg b. w, 500 mg/kg b. w, respectively showed a significant reduction in TC, LDL, VLDL and TG on 28th days in GP F(rats treated with 250 mg/kg b. w”Bayad” fish oil) , while showed a significant reduction in TC and LDL in GP K(rats treated with 250 mg/kg b. w ”Kaparose” fish oil) when compared to cholesterol group(GP B).Group F (rats treated with 250 mg/kg b. w “Bayad “ fish oil) showed a significant (P<0.05) reduction in TC, VLDL and TG on 28th days , while group K(rats treated with 250 mg/kg b. w “Kaparose” fish oil) showed a significand (P<0.05) reduction in TC when compared to standard drug(Atorvastatin).

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