WORLD JOURNAL OF ADVANCE
HEALTHCARE RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Review Journal for Medical Science and Pharma Professionals

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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ISSN 2457-0400

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Indexing

  Indexing

  • Google Scholar
  • Index Copernicus
  • SOCOLAR, China
  • Research Bible, Fuchu, Tokyo. JAPAN
  • Cosmos Impact Factor
  • Scientific Indexing Services (SIS)
  • UDLedge Science Citation Index
  • International Impact Factor Services
  • International Society for Research Activity (ISRA) Journal Impact Factor (JIF)
  • IFSIJ Measure of Journal Quality
  • Scientific Journal Impact Factor (SJIF)
  • International Scientific Indexing, UAE (ISI) (Under Process)
  • International Impact Factor Services (IIFS)
  • Web of Science Group (Under Process)
  • Directory of Research Journals Indexing
  • Scholar Article Journal Index (SAJI)
  • International Scientific Indexing ( ISI )
  • Academia
  • Scope Database

Abstract

COMPARATIVE STUDIES OF THE ANTIFUNGAL ACTIVITIES OF THE LEAF EXTRACTS OF LOCALLY GROWN CYMBOPOGON CITRATUS AND CONVENTIONAL ANTIFUNGAL DRUGS AGAINST CANDIDA ALBICANS ISOLATED FROM PATIENTS ATTENDING A TERTIARY HOSPITAL IN ABAKALIKI, EBONYI STATE

Ohoke Claire O., Udu-Ibiam Onyinyechi E.*, Chukwu Sunday K., Andoackaa Austin D., Ikporo Julius O.

ABSTRACT

Candida albicans is a common commensal fungus that colonizes the oropharyngeal cavity, gastrointestinal tract, vaginal tract, and skin of healthy. One hundred (100) clinical samples of urine were collected from patients attending Alex Ekwueme Federal Teaching Hospital Abakaliki, Ebonyi state using sterilized clinical urine container out of which 20 samples of male patients tested, 5 (16.13%) were positive and 80 samples of female, 26 (83.17%) were positive. From the distribution, the female had more number of Candida albicans than male as observed. The antifungal susceptibility test was carried out using the Kirby-Bauer disc diffusion method. The following antifungal drugs were used: Flucytosine (1μg), Amphotericin B (10μg), Fluconazole (100μg) and Griseofulvin (10μg) The zone of inhibition of the equally tested extracts of Cymbopogon citratus showed that the 100 mg/ml extract showed more inhibition than the 50mg/ml and 25mg/ml with the highest IZD being 18mm and lowest 2mm. The organism showed high susceptibility rate to flucytosine, accounting 77.42% susceptibility rate, 9.68% resistance and 12.90% no inhibition. The organism also showed varying percentage of susceptibility to amphotericin B and griseofulvin, at 38.71% and 3.23% respectively, the resistance rate of 22.58% and 16.13% respectively and the percentage rate of no inhibition is 38.71% and 80.65% respectively. Fluconazole showed the highest rate of susceptibity at 74.19%, 25.81% were resistance. This shows that comparatively that the extract of Cymbopogon citratus holds a promising note in microbial remedies using natural products.

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