WORLD JOURNAL OF ADVANCE
HEALTHCARE RESEARCH

Mustafa Mohammed Abd Alwahid* and Dr. Ala Hussain Haider

ABSTRACT

BackgroundSerum gamma glutamyl transferase is an enzyme involved in glutathione metabolism, has been implicated in oxidative stress and inflammation, both key contributors to atherosclerosis and coronary artery disease. Aim of the study to Evaluate gamma glutamyl transferase's predictive role in coronary disease severity and establish correlations with coronary heart disease risk factors. Patients and Methods a cross-sectional study conducted in Merjan teaching hospital and Shaheed Al-Mehrab Cardiovascular center from the 1st Jan 2023 to the 1st Oct 2023. The study involved the assessment of 100 patients scheduled for coronary angiography due to suspected coronary artery disease. The gamma glutamyl transferase measurements were conducted using established laboratory techniques. An elevated level was deemed to be present when it exceeded 71 IU/L in male patients and 42 IU/L in female patients according to laboratory reference values. Results The mean age of the patients was 60.5 ± 11.3, regarding sex distribution, 60 percent were male and 40 percent were female. In this study, gamma glutamyl transferase levels, with a median of 40.5 (IQR: 21.0-56.2), showed elevation in 24.0% of patients. A comparison between normal and abnormal angiography revealed significantly higher gamma glutamyl transferase levels (46.0 vs. 23.0, p < 0.001) in the latter group. Conclusion The current study concluded that serum gamma-glutamyl transferase is prevalent among those with ischemic heart disease, revealing a significant association with positive angiography findings.

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