WORLD JOURNAL OF ADVANCE
HEALTHCARE RESEARCH

Rasha Alaje*, Deeb Bakir and Shuaib Alahmad

ABSTRACT

In this study, we investigated the electrochemical direction of the antibiotic ciprofloxacin (CIP) using the glassy carbon electrode as the working electrode and Silver/silver chloride) Ag/AgCl) electrode as comparative electrode, employing the cyclic voltammetric method. We examined the impact of varying concentrations on the electrochemical direction of CIP, observing a single cathodic wave during scans towards the most negative potentials. No wave was observed during scans in the opposite direction, indicating a one-stage controlled process of CIP direction with supported by a correlation coefficient R2 = 0.9987. To understand the transfer mechanism and kinetics of CIP molecules, we explored the effect of scanning speed on the electrochemical direction behavior of CIP by varying scanning rates (20-40-60-80-and100mV/s) at a constant CIP concentration. Our findings revealed that the movement of ciprofloxacin molecules from the solution to the glassy carbon electrode surface follows diffusional kinetics in a moderate medium. Additionally, we observed a linear increase in peak current with rising reactant concentration, with a correlation coefficient R2 = 0.9996. Continuing with the analytical and practical aspects of our research, we detected ciprofloxacin in pharmaceutical formulations. We examined a pharmaceutical tablet approved by the Syrian Ministry of Health and manufactured by (Medico), revealing that themedication content in the tablet was 98.23%. This percentage falls within the acceptable range as per the American and British Pharmacopoeia standards (90-110%).

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