WORLD JOURNAL OF ADVANCE
HEALTHCARE RESEARCH

Huda Abd Alhameed*, Mohammad Keshe, Rasha Alabbas and Omar Alkhuder

ABSTRACT

In this paper the reaction of propyl 4-nitrobenzoate with acetophenone to prepare 1-(4-nitrophenyl)-3-phenylpropane-1,3-dione was carried out using appropriate conditions, where a homogeneous basic catalyst (tetrabutyl ammonium hydroxide) was used with a molar ratio (1:1) (propyl 4-nitrobenzoate: Acetophenone), at a temperature of 45°C and a reaction time of 14 hours. The desired product was obtained with high selectivity and high yield (76%). After that, some physical properties of the reaction product were determined by measuring the turbidity and density of the aqueous solution. After that, the biological activity of the product was studied on two types of bacteria "positive and negative gram" and compared it with a reference substance "gentamicin", The results of the study show an average ability to inhibit the growth of negative bacteria and a better ability to inhibit the growth of positive bacteria at the concentrations studied compared to the reference substance (gentamycin). The product was separated and purified, the molecular structures have determinate by spectroscopy methods FT–IR, 1H–NMR, 13C–NMR.

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