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Abstract
METHOTREXATE: FRIEND OR FOE?
*Pradeep Marur Venkategowda, Anusha Raj, Himaal Dev G. J. and Chaitra C. Rao
ABSTRACT
Methotrexate (MTX) is a life-saving drug used to treat various clinical conditions. Complications due to low-dose MTX are extremely rare. A 55-year-old woman with multiple health conditions was prescribed low-dose methotrexate (7.5 mg twice weekly) for arthritis. However, she developed various complications, including fever, cough, breathlessness, oral and perianal ulcers, and pancytopenia, indicating methotrexate toxicity. Imaging revealed lung abnormalities. The patient was received in intensive care and treated with antibiotics, ventilation support, hemodialysis, and blood components. Fortunately, her condition improved, and she was discharged (on request) early due to financial constraints. This case highlights serious risks associated with low-dose methotrexate and the importance of early recognition and treatment to minimize harm.
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