WORLD JOURNAL OF ADVANCE
HEALTHCARE RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Review Journal for Medical Science and Pharma Professionals

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  • Google Scholar
  • Index Copernicus
  • SOCOLAR, China
  • Research Bible, Fuchu, Tokyo. JAPAN
  • Cosmos Impact Factor
  • Scientific Indexing Services (SIS)
  • UDLedge Science Citation Index
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  • International Society for Research Activity (ISRA) Journal Impact Factor (JIF)
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Abstract

EVALUATION OF THE ANTIBACTERIAL ACTIVITY OF HYDROETHANOLIC AND AQUEOUS EXTRACTS OF PICRALIMA NITIDA (APOCYNACEAE) ON BACTERIAL ETIOLOGIES OF GASTROENTERITIS

Yvanna Sandra Tsakam Ngoupeyou, Anselme Michel Yawat Djogang*, Simo Louokdom Josué, Yimta Foutse Wandji and Pierre René Fotsing Kwetche

ABSTRACT

Herbal therapy is an ancient form of medicine. It utilizes entire plants or their parts to prevent or treat various diseases thanks to medicinal properties. Bacterial gastroenteritis contribute significantly to healthcare-related burden. The present investigation aimed at evaluating the antibacterial properties of hydroethanolic and aqueous extracts from Picralima nitida leaves, bark, and roots on common bacterial etiologies of gastroenteritis. Extraction was performed by maceration with 70% ethanol and water. It was followed by qualitative and quantitative phytochemical analysis. The antibacterial activity was assessed using the macrodilution method on solid medium against four quinolone-resistant bacterial types that are commonly associated to gastrointestinal infections. Results revealed varying extraction yields, with the highest recorded with the hydroethanolic maceration of leaves (22.2%). Phytochemical screening identified several bioactive compounds, with the highest concentrations in total phenols. Minimum Inhibitory Concentrations (MICs) ranged from 8.3 ± 2.5 through 166.7 ± 44.4) mg/mL. Bactericidal potential was also observed. These findings suggest the potential of hydroethanolic and aqueous extracts of Picralima nitida in managing infections caused by quinolone-resistant bacteria. These results may justify at least partially the traditional use of P. nitida in herbal medicine and emphasize the importance of policies promoting sustainable production of Picralima nitida.

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