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Abstract
UNVEILING SUBTLE MYCOBACTERIUM TUBERCULOSIS INFECTION WITH UNUSUAL RIFAMPICIN SUSCEPTIBILITY: A CASE STUDY UTILIZING XPERT MTB/RIF
A. Rakesh Reddy*, Basani Pavithra, Samreddy Bhavani, Degam Akshaya, Rasuri Charishma and Dr. Shiva Raju
ABSTRACT
Extrapulmonary tuberculosis (EPTB) poses diagnostic dilemmas due to its varied clinical presentations and the absence of classical symptoms. Here, we present the case of a 71-year-old female exhibiting intermittent fever, chills, generalized weakness, and joint pains, alongside extensive lymphadenopathy involving cervical, supraclavicular, and axillary regions. PET-CT imaging revealed metabolically active lymph nodes, prompting biopsy confirmation of Mycobacterium tuberculosis (MTB) via GeneXpert, despite negative acid-fast bacilli (AFB) testing. Notably, low MTB levels with no rifampicin resistance were detected. This case underscores the critical role of advanced diagnostic modalities, particularly GeneXpert, in identifying EPTB, especially in scenarios with low bacterial burden. Effective management, guided by precise diagnosis, ensured favourable patient outcomes.
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