WORLD JOURNAL OF ADVANCE
HEALTHCARE RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Review Journal for Medical Science and Pharma Professionals

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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Indexing

Abstract

THE EFFECT OF ZINC GLUCONATE SUPPLEMENTATION ON QUALITY OF SLEEP AND SERUM ALBUMIN IN PATIENTS UNDERGOING MAINTENANCE HEMODIALYSIS IN MEDICAL CITY DIALYSIS CENTER / BAGHDAD

*Alyaa Mohammed Zaki Hussein and Ban Abdul-Ridha Al-Hashimi

ABSTRACT

Introduction: Chronic kidney disease (CKD), particularly in its advanced stages managed by maintenance hemodialysis, presents a complex challenge affecting multiple aspects of health, including nutritional status, metabolic balance, and overall quality of life, the aim of study is to determine if zinc gluconate supplementation improves sleep and serum albumin in maintenance hemodialysis patients. Method: A single-blind clinical trial will be conducted at the Medical City Dialysis Center in Baghdad from 1st of September 2023 to 1st of January 2024, involving 50 end stage renal disease (ESRD) patients on maintenance hemodialysis. Participants will be divided 2 groups; 1st group will receive 25 mg of zinc gluconate daily for 12 weeks, while the 2nd group will receive a placebo. Sleep quality, assessed by the Pittsburgh Sleep Quality Index, and serum albumin concentrations were measured at the baseline and at the end of the study, with sociodemographic factors also considered for potential correlations. Result: In a study involving ESRD patients on hemodialysis, zinc supplementation led to significant changes in serum zinc and albumin levels over a 3-month period. Patients receiving zinc showed increased serum albumin and improved sleep quality, evidenced by decreased Pittsburgh Sleep Quality Index scores. These findings suggest beneficial effects of zinc supplementation on serum albumin and sleep in hemodialysis patients. Conclusion: In clinical trials, zinc supplementation dramatically raises blood zinc levels in hemodialysis patients compared to baseline and a placebo group. Zinc supplementation also raised serum albumin, indicating better nutrition. Additionally, the supplementation improved sleep quality, as seen by a substantial drop in Pittsburgh Sleep Quality Index scores. Zinc may help manage end-stage renal disease and hemodialysis problems, according to these studies. Confirming these findings and investigating long-term benefits and appropriate dose is advised.

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