WORLD JOURNAL OF ADVANCE
HEALTHCARE RESEARCH

*Raed Mahmood Faraj, Kadhim Challoob Hasan and Sarah Mohammed Saeed

ABSTRACT

Background: About 10% of people develop a peptic ulcer, and perforation is one of the most dangerous consequences that requires immediate surgery. As stomach contents enter the peritoneal cavity, chemical peritonitis begins, and if left untreated, bacterial contamination, intra-abdominal abscess development, and sepsis will occur from continuous leaking. Objectives: to determine the risk factors that influence perforation in peptic ulcer disease, morbidity and post-surgical complications and management. Method: The study included 68 patients with perforated peptic ulcer who were admitted to Al-Hilla general hospital and Al-Imam Al-Sadiq teaching hospital in Hilla/Babil/Iraq from October 1, 2021, to October 1, 2022. Only surgically treated patients who could be followed until hospital discharge were included. Results: The incidence is higher in males than females, smokers and NSAID and steroid users were high, age and other comorbidities increase mortality and post-surgical complications, and the longer the time from symptom onset to hospital arrival, the higher the Mannheim peritonitis index at initial presentation. Duodenum perforation is the most prevalent location, with 0.5-1 cm diameters and surgical wound infection being the most common post-surgery consequence. Conclusion: Smoking and unsafe NSAID use are risk factors for perforation in male patients, with the duodenum being the most common site. However, complications can still occur despite proper management, and early diagnosis and treatment can reduce morbidity and mortality.

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