WORLD JOURNAL OF ADVANCE
HEALTHCARE RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Review Journal for Medical Science and Pharma Professionals

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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Indexing

  Indexing

  • Google Scholar
  • Index Copernicus
  • SOCOLAR, China
  • Research Bible, Fuchu, Tokyo. JAPAN
  • Cosmos Impact Factor
  • Scientific Indexing Services (SIS)
  • UDLedge Science Citation Index
  • International Impact Factor Services
  • International Society for Research Activity (ISRA) Journal Impact Factor (JIF)
  • IFSIJ Measure of Journal Quality
  • Scientific Journal Impact Factor (SJIF)
  • International Scientific Indexing, UAE (ISI) (Under Process)
  • International Impact Factor Services (IIFS)
  • Web of Science Group (Under Process)
  • Directory of Research Journals Indexing
  • Scholar Article Journal Index (SAJI)
  • International Scientific Indexing ( ISI )
  • Academia
  • Scope Database

Abstract

NATURAL DISINTEGRANTS: ROLE IN PHARMACEUTICAL FORMULATION

Abhishek Pandey* and Satyawan Dangi

ABSTRACT

Disintegrants are agents which are integrated to tablets and some encapsulated formulations in order to promotethe breakup of the tablet and capsule “slugs” into more small fragments in an aqueous environment whichthereafter increment the available surface area and promoting a more rapid release of the drug substance. Thedevelopment of new excipients for potential use as disintegrant agent in tablet formulations continues to be ofinterest. This is because different disintegrant agents can be useful in promoting penetration of moisture anddispersion of the tablet matrix and disintegration of tablet has received considerable attention at present as anessential step in obtaining fast drug release. Natural polymers such as starches, gums, mucilage, and dried fruitsutilized as binder, diluent, and disintegrants to increase the solubility of poorly water-soluble drug, decrease thedisintegration time, and provide nutritional supplement. Natural disintegrants are safe and economical thansynthetic disintegrants such as Polyvinylpyrrolidone (PVP). Therefore, in the present review, an attempt has beenmade to reveal the importance of the natural disintegrants in the pharmaceutical formulations.

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