WORLD JOURNAL OF ADVANCE
HEALTHCARE RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Review Journal for Medical Science and Pharma Professionals

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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ISSN 2457-0400

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Indexing

  Indexing

  • Google Scholar
  • Index Copernicus
  • SOCOLAR, China
  • Research Bible, Fuchu, Tokyo. JAPAN
  • Cosmos Impact Factor
  • Scientific Indexing Services (SIS)
  • UDLedge Science Citation Index
  • International Impact Factor Services
  • International Society for Research Activity (ISRA) Journal Impact Factor (JIF)
  • IFSIJ Measure of Journal Quality
  • Scientific Journal Impact Factor (SJIF)
  • International Scientific Indexing, UAE (ISI) (Under Process)
  • International Impact Factor Services (IIFS)
  • Web of Science Group (Under Process)
  • Directory of Research Journals Indexing
  • Scholar Article Journal Index (SAJI)
  • International Scientific Indexing ( ISI )
  • Academia
  • Scope Database

Abstract

IN SILICO STUDIES ON DENGUE AND NIPAH VIRAL PROTEINS WITH SELECTED AZADIRACHTA INDICA LEAVES CONSTITUENTS

Archana S., Smriti Chawla, Bhavya M., Ramya M., Anushree S. and *Balasubramanian Sathyamurthy

ABSTRACT

Dengue vrirus contains seven proteins and Nipah virus contains five proteins, which are considered to be most potent for drug designing. Recent studies have shown that these proteins can effectively cause the deactivation of dengue and nipah disease in humans. Azadirachta indica phytochemicals are found to have anti-bacterial and anticancer properties. In this study, the binding efficiency of five compounds that are present in the Azadirachta indica with all the twelve proteins through Insilico methods was carried out. By our virtual screening and molecular docking result, we found that the 3,7,11,15- tetramethyl-2-hexadecen-1-ol and 8,11,14- Eicosatrienoic acid have highest binding affinities with the proteins.

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