WORLD JOURNAL OF ADVANCE
HEALTHCARE RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Review Journal for Medical Science and Pharma Professionals

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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ISSN 2457-0400

Impact Factor  :  6.711

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    Venue: FCT Education Resource Center, Abuja-Nigeria

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Best Article of current issue

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Indexing

Abstract

THE SKELETAL STATUS OF CHILDREN WITH STEROID SENSITIVE NEPHROTIC SYNDROME BY DUAL-ENERGY X RAY ABSORPTIOMETRY DXA SCAN

Israa A. Hammoodi*, Abdulbari Abdulhaleem M. Al-Mashhadani and Muna Hussam Alden Ismael

ABSTRACT

Objective: The study performed for evaluation of BMD in idiopathic nephrotic syndrome in children using Dual–energy X ray absorptiometry (DXA). Methods: Cross sectional study performed on 70 patients with aged 4-18years old, 36 patients with infrequent relapse (group A) and 34 patients with frequent relapsing and steroiddependent NS (group B) followed up in pediatric nephrology clinic in Ibn sina teaching hospital in mosul city.Complete evaluation of patients including thorough history, physical examination and laboratory investigationincluding vitamin D level and PTH. DXA Scan used to assess LSS BMD and Total Hip BMD Z Scores. Results:The study show prevalence of vitamin D deficiency with male predominance, greater steroid dose and longerduration associated with negative effect on BMD. Increase PTH and total alkaline phosphatase level significantlyespecially in group B. Predominance of average LSS BMD 54.28% then osteopenia in 27.14% and osteoporosis in18.57%. Conclusion: The use of steroid in nephrotic syndrome in children have negative impact on the bonemineral density. Abbreviation: SSNS = steroid sensitive nephrotic syndrome, NS =nephrotic syndrome, BMD=bone mineral density, PTH = parathyroid hormone.

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