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Abstract
COMPARATIVE EVALUATION OF SCHIZANDRA FRUIT AND VITAMIN E ON LEARNING AND MEMORY BEHAVIOUR IN EXPERIMENTAL MODEL OF STRESSED SWISS CDI MICE
Joffa P. P. K.*, Erigbali P. P., Egbejimi A. M., Kiridi E. G. and Dabirilagha O. F.
ABSTRACT
Schizandra fruit and vitamin E were evaluated for comparative cognitive health benefits in Swiss mice. Stress was induced in rodents pre-administered with schizandra and vitamin E, within experimentally designed scope. Thereafter, they were assessed alongside non-treated control rodents with Neurobehaviour parameters (swim latency, retention quadrant duration, annulus crossings, percentage % correct entry); that depict learning and memory, using established protocols of Morris water maze and spontaneous alternation test. From the observations, treatment with schizandra (referential) and vitamin E (known standard pill) both enhanced visuospatial memory in stressed mice, with vitamin E appearing more potent. Although isolated investigation of active ingredient in schizandra may be more hopeful.
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