WORLD JOURNAL OF ADVANCE
HEALTHCARE RESEARCH

Dr. Rand Nibras Zaki* and Dr. Alaa Ghani Hussein

ABSTRACT

Introduction: Ovarian cancer is one of the leading causes of mortality in women, and is the fifth most prevalentcancer in Iraqi women, it’s classified as epithelial tumors, representing almost 90% of cases, mesenchymal tumors,mixed epithelial and mesenchymal tumors, sex cord stromal tumors representing (2%) of cases, germ cell tumorsrepresenting (3%) of cases, miscellaneous tumors and tumor-like lesions. The risk of developing ovarian cancerincreases with age. Symptoms may include pelvic pain or tender- ness, swollen abdomen, nausea or dysphagia,changes in bowel habits (constipation), and irregular vag- inal bleeding. To assess the histopathological diagnosisof malignant ovarian tumors in a group of Iraqi female patients in Baghdad discrete in correlation with variousclinicopathological parameters (Age, Clinical presentation, Gross morphology, Histopathological type and Tumorgrade, and pathological stage). Methods: Study including analysis of 70 female patients with ovarian malignanciesfrom Teach- ing Laboratories of al Emamain al kadhimain medical city (AS) and Baghdad Medical City fromJanuary 2018 to December 2022. The data were collected from patient archived pathological report, collectedsamples were formalin fixed paraffin embedded blocks and hematoxylin and eosin-stained slides, new sectionsfrom each block were taken, stained with hematoxylin and eosin. The data were statistically analyzed usingappropriate statistical techniques (SPSS) version 26 measuring mean, standard deviation, frequency, percentage, andthe association relationships were investigated using yates CHI square test, P value of <0.05 was consideredstatistically significant. Results: The patients’ age ranged from 9-76 years with a mean of 44.81 years ± 15.16 SD.Most were at age group ≤ 50 years, the most common histopathological type was high grade serousadenocarcinoma in 24.28, that is to say the epithelial tumors were the most frequent (54.27%). Most cases presentedwith abdominal pain (31.43%) and least frequent presentation was weight loss (1.43%), most tumors presented asmass (55.71%) unilateral (61.43%) and right sided (53.49%), tumor size ranged from 3.5-20cm with a mean of(11.59 ± 4.16 SD). As for grading, most were in grade III (44.28%). And half the cases were stage III (50%).Conclusion: The most common histopathological type was high grade serous adenocarcinoma, which means theepithelial tumors were the most frequent Most malignant tumors of the ovary in patients are of large size andpresent at ad- vanced stage and higher nuclear grade, this is due to late presentation of patients after disease progression.

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