WORLD JOURNAL OF ADVANCE
HEALTHCARE RESEARCH

Erigbali P. P.*, Egbejimi A. M., Sule O. J. and Owotgwun K. L.

ABSTRACT

The cardiopulmonary-protective potential of Elaeis guineensis (oil palm) seed extract on mosquito coil toxicity was investigated in experimental rat model. Thirty-six (36) male wistar rats were grouped into six: Group I had normal pellets along with distilled water, Group II was exposed to mosquito coil smoke (as repellent) for 1 hour daily, Group III was exposed to repellent with oral administration of 2ml/kg body weight of Vitamin E, Groups IV and V were exposed to repellent with oral administration of oil palm seed extract at doses of 2ml/kg and 4ml/kg body weight, respectively, and Group VI received oral administration of only oil palm seed extract at a dose of 2ml/kg body weight. Results revealed a significant increase in creatine kinase and lactate dehydrogenase (cardiac markers) in Group II compared to the normal control (Group I). Additionally, oxidative stress markers and lipid peroxidation levels were significantly elevated in Group II when compared to group I (normal control). However, groups (IV, V and VI) administered with 2ml/kg and 4ml/kg body weight of Elaeis guineensis seed extract showed a significant decrease in these markers compared to the positive control (Group II). In conclusion, the observed improvements in biochemical markers and oxidative stress markers suggest that oil palm seed may have served as a natural agent against cardiopulmonary toxicity induced by mosquito coil fumes and possibly proffered cardiopulmonary protection in those groups of rats which were exposed to mosquito coil fumes.

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