WORLD JOURNAL OF ADVANCE
HEALTHCARE RESEARCH

*Noora M. Kareem, Maab Moyaser Hameed and Bashar A. Abdul Hassan

ABSTRACT

Background: Breast cancer is one of the top causes of cancer-related death in women globally, and earlyidentification improves prognosis and survival. Screening mammography detects asymptomatic breastabnormalities. Not all screening mammogram lesions are cancerous, thus additional investigation is needed toestablish their type. FNAC and CB are minimally invasive procedures for histopathological tissue sampling. Theaim of study is to evaluate and compare the effectiveness of fine-needle aspiration cytology (FNAC) and coreneedle biopsy (CNB) as preoperative diagnostic tools for breast cancer identified through screening. Method:Cross-sectional study of 75 breast cancer patients from June 2023 till December 2023 in Al-ImamainAlkadhomain medical city. Age, core biopsy (B4a, B4b, B4c, B5), cytology diagnosis (Positive, Suspicious), andultrasound diagnostic (carcinoma, duct ectasia, fibro adenomas) are obtained for all females. Results: In a studycomparing diagnostic methods for breast cancer, 32% of females aged 50-59 and 26.7% aged 60+ were evaluated.Core biopsy revealed 29.3% at B4b stage and 18.1% at B4a, whereas cytology diagnosed 37.3% with carcinoma,and ultrasound detected 90.7% with breast cancer. Significant correlations were found between cytology and corebiopsy diagnoses, with high concordance rates in B5 and B4a stages, but no significant association betweenultrasound and core biopsy. Ultrasound showed a 41.2% sensitivity and 100% specificity when compared tocytology. Conclusion: In breast cancer diagnosis, cytology and core biopsy results are strongly correlated,demonstrating their complimentary roles in disease characterization. Although ultrasound diagnoses did notcorrelate with core biopsy findings, ultrasound had excellent specificity and moderate sensitivity for cytologyoutcomes. These findings highlight the necessity of merging cytology and core biopsy in breast cancer diagnosisto improve preoperative evaluations and influence treatment decisions.