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Abstract
A STUDY ON COMBINATIONS FOR STATINS AND CLOPIDOGREL; CLINICAL REVIEWS AND ITS RISK AMANGEMENT IN COMBINATION THERAPY
*P. Priyanka, P. Alekhya and D. Sudharshini
ABSTRACT
Stroke is a clinically defined syndrome of acute, focal neurologicaldeficit attributed to vascular injury (infarction,haemorrhage) of the central nervous system. Stroke is the second leading cause of death and disability worldwide.Stroke is not a single disease but can be caused by a wide range of risk factors, disease processes and mechanisms.Hypertension is the most important modifiable risk factor for stroke, although its contribution differs for differentsubtypes. It is caused by when there is a disruption of blood flow to the brain, resulting in damage to brain cells.In this we have focused on drugs interactions of Clopidogrel and atorvastatin drugs are most common drugs instroke conditions then we found an interaction in that because atorvastatin reduces the ability of Clopidogrel toinhibit platelet aggregation because atorvastatin is metabolized by cytochrome p450(CYP) 3A4 we hypothesizedthat Clopidogrel might be activated by CYP3A4. So that it get interaction between Clopidogrel and atorvastatin sowehave to alter the drug or we have to reduce the dose of drugs.
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