WORLD JOURNAL OF ADVANCE
HEALTHCARE RESEARCH

*Noor Fadhil Abbas, Besmah M. Ali and Bassam Francis Matti

ABSTRACT

Background: Beta Thalassemia Major (BTM) is a severe hereditary blood condition that causes anaemia andother consequences by reducing or eliminating haemoglobin beta chain production. These issues have drawnattention to crucial trace elements like zinc. Enzymatic activity, immunological function, and DNA synthesisdepend on zinc, a trace element. BTM patients typically have abnormal zinc metabolism, which might affect theirhealth and illness treatment. The aim of study is to evaluation the association between serum zinc and serumferritin in patients with beta thalassemia major. Method: This study involved 90 thalassemia patients from aprivate lab in Al-Najaf city, analyzing their age, gender, spleen status, blood transfusion frequency, and blood unitusage, along with serum zinc and ferritin levels, using an Italian-made zinc kit from January to October 2023.Exclusions included pregnant women, those on contraceptives, and patients with certain medical conditions.Ethical approval and verbal consent were obtained, ensuring privacy and anonymity. Results: In a study of 90thalassemia patients, 15.5% had a splenectomy, and 63.4% required frequent blood transfusions. The study foundno significant differences in serum ferritin and zinc levels across various demographics and conditions within thethalassemia group. However, thalassemia patients had higher mean ferritin levels compared to a control group,with no notable differences in zinc levels between the two groups. Conclusion: The study on Beta ThalassemiaMajor patients shows that serum ferritin and zinc levels are consistent across different demographics andtreatments in thalassemia patients, indicating stable zinc metabolism despite varied conditions. Thalassemiapatients have higher serum ferritin levels than controls, highlighting iron overload, but their zinc levels are similarto those of the controls. These findings are significant for clinical management and nutritional monitoring ofthalassemia.