News & Updation
Best Paper Awards
World Journal of Advance Healthcare Research (WJAHR)Honored the authors with best paper award, monthly based on the innovation of research work. Best paper will be selected by our expert panel.
Best Article of current issue
Download Article : Click here
FORMULATION OF METFORMIN HYDROCHLORIDE CONTROLLED RELEASE MATRIX TABLETS, AND ANALYTICAL METHOD USED IN THE DETERMINATION OF METFORMIN HCL
Dr. Mekala Sunil*, Dr. Y. Evangelin, B. Koteswaramma, K. Venkata Narasimha Rao, M. Syamsundaram, T. Manaikya and V. Lakshmi Prasanna Devi
Metformin hydrochloride has relatively short plasma half-life, low absolute bioavailability. The need for theadministration two to three times a day when larger doses are required can decrease patient compliance. Sustainedrelease formulation that would maintain plasma level for 8-12 h might be sufficient for daily dosing of metformin.Sustained release products are needed for metformin to prolong its duration of action and to improve patientcompliances. The overall objective of this study was to develop an oral sustained release metformin hydrochloridetablet by using hydrophilic The in vitro dissolution study was carried out using USP 22 apparatus I, paddlemethod and the data was analysed using zero order, first order, Higuchi, Korsmeyer and Hixson-Crowellequations. Kinetic modeling of in vitro dissolution profiles revealed the drug release mechanism ranges fromdiffusion controlled or Fickian transport to anomalous type or non-Fickian transport. Fitting the in vitro drugrelease data to Korsmeyer equation indicated that diffusion along with erosion could be the mechanism of drugrelease.[Full Text Article] [Download Certificate]