WORLD JOURNAL OF ADVANCE
HEALTHCARE RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Review Journal for Medical Science and Pharma Professionals
World Journal of Advance Healthcare Research (WJAHR) has indexed with various reputed international bodies like : Google Scholar , Index Copernicus , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , Cosmos Impact Factor , Scientific Indexing Services (SIS) , UDLedge Science Citation Index , International Impact Factor Services , International Society for Research Activity (ISRA) Journal Impact Factor (JIF) , IFSIJ Measure of Journal Quality , Scientific Journal Impact Factor (SJIF) , International Scientific Indexing, UAE (ISI) (Under Process) , International Impact Factor Services (IIFS) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Academia , Scope Database , 

ISSN 2457-0400

Impact Factor  :  6.711

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World Journal of Advance Healthcare Research (WJAHR)Honored the authors with best paper award, monthly based on the innovation of research work. Best paper will be selected by our expert panel.

Best Article of current issue

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Indexing

Abstract

FORMULATION OF METFORMIN HYDROCHLORIDE CONTROLLED RELEASE MATRIX TABLETS, AND ANALYTICAL METHOD USED IN THE DETERMINATION OF METFORMIN HCL

Dr. Mekala Sunil*, Dr. Y. Evangelin, B. Koteswaramma, K. Venkata Narasimha Rao, M. Syamsundaram, T. Manaikya and V. Lakshmi Prasanna Devi

ABSTRACT

Metformin hydrochloride has relatively short plasma half-life, low absolute bioavailability. The need for theadministration two to three times a day when larger doses are required can decrease patient compliance. Sustainedrelease formulation that would maintain plasma level for 8-12 h might be sufficient for daily dosing of metformin.Sustained release products are needed for metformin to prolong its duration of action and to improve patientcompliances. The overall objective of this study was to develop an oral sustained release metformin hydrochloridetablet by using hydrophilic The in vitro dissolution study was carried out using USP 22 apparatus I, paddlemethod and the data was analysed using zero order, first order, Higuchi, Korsmeyer and Hixson-Crowellequations. Kinetic modeling of in vitro dissolution profiles revealed the drug release mechanism ranges fromdiffusion controlled or Fickian transport to anomalous type or non-Fickian transport. Fitting the in vitro drugrelease data to Korsmeyer equation indicated that diffusion along with erosion could be the mechanism of drugrelease.

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