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World Journal of Advance Healthcare Research (WJAHR)Honored the authors with best paper award, monthly based on the innovation of research work. Best paper will be selected by our expert panel.
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Abstract
COSTUS AFER KER GAWL RHIZOME ETHYL ACETATE FRACTION MITIGATED DICLOFENAC-INDUCED RENAL TOXICITY IN MALE WISTAR RATS BY SUPPRESSING OXIDATIVE STRESS
L. O. Olajide*, B. O. Adeoye, N. B. Amadi, O. S. Olajide, M.O. Adetayo, B. T. Ogunbiyi and A. D. Adeoye
ABSTRACT
This study aims to evaluate the preventive effect of Costus afer ker Gawl rhizome ethyl acetate fraction (CAREAF) on diclofenac-induced renal toxicity. In vitro antioxidant activity was evaluated using TAC and DPPH assays. In vivo study, thirty-six (36) male Wistar rats were randomly divided into six groups (n=6), namely normal, induced not treated, reference drug quercetin (10 mg/kg), extract treated groups (100, 300, and 500 mg/kg b.w.) for 14 days. The animals were induced using diclofenac sodium (200 mg/kg b.w.) after treatment and sacrificed 24 hours after induction. The result showed that C. afer rhizome is high in antioxidant capacity from DPPH and TAC assay activity as compared to that of standard (gallic acid) and in vivo antioxidant activity also increased in SOD and CAT with reduced MDA. The renal function test showed decreased levels of urea and creatinine in the groups treated with 100, 300, and 500 mg/kg b.w. in a dose-dependent manner. These findings suggest that the ethyl acetate fraction of Costus afer rhizome may have therapeutic potential in mitigating renal damage caused by diclofenac sodium.
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