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IN VITRO EVALUATION OF THE EFFECT OF YERBA MATE ON WARFARIN EFFICACY
Karol Saeed*, Dima Aldiab and Nouma Hasan
Yerba mate (YM) is a popular tea in Arab countries especially Syria, it is made from the infusion of the dried leaves of Ilex paraguariensis. Traditional and composed YM are a rich source of polyphenols. Warfarin is a widely prescribed anticoagulant drug with a narrow therapeutic index. Warfarin is known for its significant and extensive interaction with food and other drugs. This study aimed to investigate the effects of different concentrations of YM extract on the international normalized ratio (INR) of patients who receive Warfarin. We prepared many concentrations of each traditional and composed YM. The total polyphenolic content was determined using a spectrophotometric assay at 750 nm. The anticoagulant effect was evaluated by calculating the international normalized ratio INR depending on prothrombin time (PT). The results showed that the phenolic content of composed YM was (106.88 mgGAE/g) which was higher than the one of the traditional YM (90.47 mgGAE/g). In-vitro PT test showed that both traditional and composed YM could prolong prothrombin time and INR, in a concentration dependent manner. All results indicated that YM could interact with Warfarin and unfortunatly might cause bleeding.[Full Text Article]