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World Journal of Advance Healthcare Research (WJAHR)Honored the authors with best paper award, monthly based on the innovation of research work. Best paper will be selected by our expert panel.
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DETERMINATION OF PIOGLITAZONE HYDROCHLORIDE IN BOTH PURE FORM AND PHARMACEUTICAL FORMULATIONS
Manar Alkhoury*, Deeb Bakir and Yumen Hilal
A novel, high throughput and sensitive method is described for the determination of pioglitazone hydrochloride (PGZ-HCl) as anti-diabetic in its pure form and pharmaceutical formulations. The proposed method depends on the polarographic activity of in the pH = 3.5 using by cyclic voltammetry (CV), and it showed well-defined one cathodic peak with high selectivity. Polarograms of the PGZ-HCl at (CV) in HCl at pH=3.5 exhibited six-electron irreversible cathodic peak, the peak (Ep) is in the range of potential at (-620mV to -860mV) versus Ag/AgCl. The peak may be attributed to the reduction of oxy group(-O-) and carbonyl group (-CO-). The diffusion current–concentration relationship was found to be rectilinear over the range (1.5x10-5-1.6x10-4 mol/l) at pH(3.5) for Ep using by cyclic voltammetry (CV), with limit of quantifying PGZ-HCl was 1.5 x10-5mol/l. The peaks were defined as being irreversible, diffusion-controlled although adsorption phenomenon played a limited role in the electrode process. The suggested method was novel, simple, accurate and successfully applied to the detection PGZ-HCl in pharmaceuticals and the average percentage recovery was in agreement with that obtained by the official USP method.[Full Text Article]