WORLD JOURNAL OF ADVANCE
HEALTHCARE RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Review Journal for Medical Science and Pharma Professionals

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

World Journal of Advance Healthcare Research (WJAHR) has indexed with various reputed international bodies like : Google Scholar , Index Copernicus , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , Cosmos Impact Factor , Scientific Indexing Services (SIS) , UDLedge Science Citation Index , International Impact Factor Services , International Society for Research Activity (ISRA) Journal Impact Factor (JIF) , IFSIJ Measure of Journal Quality , Scientific Journal Impact Factor (SJIF) , International Scientific Indexing, UAE (ISI) (Under Process) , International Impact Factor Services (IIFS) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Academia , Scope Database , 

ISSN 2457-0400

Impact Factor  :  6.711

News & Updation

  • Article Invited for Publication

    Dear Researcher, Article Invited for Publication  in WJAHR coming Issue.

  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.

    .

  • 6th International Conference on Human and Soci

    Venue:FCT Education Resource Center, Abuja- Nigeria                                        September 22-24, 2019

  • .

    6th INTERNATIONAL CONFERENCE ON EDUCATIONAL TECHNOLOGY AND CURRICULUM STUDIES(ICETC2019) 

     

    Venue: FCT Education Resource Center, Abuja-Nigeria

    September 22-24, 2019

  • New Issue Published

    Its Our pleasure to inform you that, WJAHR May 2024 Issue has been Published, Kindly check it on https://www.wjahr.com/home/current_issues

  • WJAHR: New Impact Factor

    WJAHR Impact Factor has been Increased to 6.711 for Year 2024.

  • WJAHR: MAY ISSUE PUBLISHED

    MAY 2024 Issue has been successfully launched on 1 MAY 2024.

Best Paper Awards

World Journal of Advance Healthcare Research (WJAHR)Honored the authors with best paper award, monthly based on the innovation of research work. Best paper will be selected by our expert panel.

Best Article of current issue

Download Article : Click here

Indexing

  Indexing

  • Google Scholar
  • Index Copernicus
  • SOCOLAR, China
  • Research Bible, Fuchu, Tokyo. JAPAN
  • Cosmos Impact Factor
  • Scientific Indexing Services (SIS)
  • UDLedge Science Citation Index
  • International Impact Factor Services
  • International Society for Research Activity (ISRA) Journal Impact Factor (JIF)
  • IFSIJ Measure of Journal Quality
  • Scientific Journal Impact Factor (SJIF)
  • International Scientific Indexing, UAE (ISI) (Under Process)
  • International Impact Factor Services (IIFS)
  • Web of Science Group (Under Process)
  • Directory of Research Journals Indexing
  • Scholar Article Journal Index (SAJI)
  • International Scientific Indexing ( ISI )
  • Academia
  • Scope Database

Abstract

DETERMINATION OF PIOGLITAZONE HYDROCHLORIDE IN BOTH PURE FORM AND PHARMACEUTICAL FORMULATIONS

Manar Alkhoury*, Deeb Bakir and Yumen Hilal

ABSTRACT

A novel, high throughput and sensitive method is described for the determination of pioglitazone hydrochloride (PGZ-HCl) as anti-diabetic in its pure form and pharmaceutical formulations. The proposed method depends on the polarographic activity of in the pH = 3.5 using by cyclic voltammetry (CV), and it showed well-defined one cathodic peak with high selectivity. Polarograms of the PGZ-HCl at (CV) in HCl at pH=3.5 exhibited six-electron irreversible cathodic peak, the peak (Ep) is in the range of potential at (-620mV to -860mV) versus Ag/AgCl. The peak may be attributed to the reduction of oxy group(-O-) and carbonyl group (-CO-). The diffusion current–concentration relationship was found to be rectilinear over the range (1.5x10-5-1.6x10-4 mol/l) at pH(3.5) for Ep using by cyclic voltammetry (CV), with limit of quantifying PGZ-HCl was 1.5 x10-5mol/l. The peaks were defined as being irreversible, diffusion-controlled although adsorption phenomenon played a limited role in the electrode process. The suggested method was novel, simple, accurate and successfully applied to the detection PGZ-HCl in pharmaceuticals and the average percentage recovery was in agreement with that obtained by the official USP method.

[Full Text Article] [Download Certificate]