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World Journal of Advance Healthcare Research (WJAHR)Honored the authors with best paper award, monthly based on the innovation of research work. Best paper will be selected by our expert panel.
Best Article of current issue
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PREVALENCE OF GLUCOSE-6-PHOSPHATE DEHYDROGENASE DEFICIENCY IN CHILDREN WITH SICKLE CELL DISEASE AT TISHREEN UNIVERSITY HOSPITAL IN LATTAKIA
Seba Ali Ebrahim*, Abdul Moneim Ghanem, Souad Sakkour
Background: Sickle cell disease(SCD) continues to be a major global public health concern due to lifelong complications associated with SCD. The coincidence of SCD with G6PD deficiency is considered an important problem that worsen the final outcome of children regarding hemolysis. Objectives: The aim of current study was to investigate the prevalence of G6PD deficiency in children with sickle cell anemia, and alterations in laboratory investigations according to presence of deficiency. Materials and Methods: A Prevalence Descriptive Study (Cross Sectional) was conducted for the period one year (2021- 2022) at Tishreen University Hospital in Lattakia-Syria. The study included group of children with SCD who were screened for G6PD deficiency and laboratory tests were compared between two groups; group I consisted of 31 patients with presence of G6PD deficiency, whereas group II consisted of 221 children without deficiency. Results: The prevalence of G6PD deficiency was 12.3% which ranges in severity from moderate (54.9%) to severe (45.1%). In females, we observed only moderate form (9.5%), whereas deficiency of G6PD ranged from moderate (3.5%) to severe (12.2%) in males. There were no significant differences between the two groups regarding age and sex (p>0.05). There were significant differences between two groups regarding HGB and MCH (group I versus group II); (7.17±0.7 versus 9.11±0.5, p:0.0001) and 24.8±1.7 versus 28.7±1.4, p:0.002) respectively and differences regarding HGB and MCH were observed significantly in males and females. Conclusion: The current study revealed that deficiency of G6PD was observed in proportion of SCD children and associated closely with the levels of HGB and MCH.[Full Text Article]