WORLD JOURNAL OF ADVANCE
HEALTHCARE RESEARCH

Soumyajit Mondal*, Soumya Chakraborty, Vedansh Upadhayay, Keshav Patwari and Dr. Dhrubo Jyoti Sen

ABSTRACT

Pharmacy is a word which runs on its two legs: chemistry & biology. Pharmacy is a harmony which has mesmerizing effect on drugs and medicines. Drug is a chemical substance which is coming from outer source having definite structural network obtained from either synthetic source, semisynthetic source or natural source [plants, animals, minerals or marine] which can fit on bio receptor platform to control the biochemical malfunction having less toxicological parameters [LD50, ED50, therapeutic index, carcinogenicity, teratogenicity, genotoxicity, neurotoxicity etc]. Drug is a formulated part called as medicine which is marketed in wholesale & retail shop stored in drug store [tablet, capsule, aerosol, cream/ointment, suppository, parenteral (large volume parenteral: LVP, small volume parenteral: SVP), transdermal, NDDS etc. The synthetic process in lab is known as wet chemistry lab and in-silico/docking process is known as dry chemistry. To find the lead compound having maximum activity with minimum toxicity is done by ADMET [administration, distribution, metabolism, excretion & toxicity] by pharmacokinetics and pharmacodynamics resembles to biochemical and physicochemical parameters of the target pharmacophore modeling. All of these follow Lipinski’s rule of five RO5 [Molecular weight <500mg, logP <5, Hydrogen bond donornot greater than ? 5, Hydrogen bond acceptor not greater than ? 10.

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