WORLD JOURNAL OF ADVANCE
HEALTHCARE RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Review Journal for Medical Science and Pharma Professionals

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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Abstract

FORMULATION DEVELOPMENT AND IN VITRO EVALUATION OF ZOLMITRIPTAN MOUTH DISSOLVING TABLETS

Jennayikode Shiva*, Sujatha Banavath, Yellareddy Challa, Ragya Eslavath, K. Sunil Kumar, R. Suthakaran and Goli Venkateshwarlu

ABSTRACT

The present study was carried out on Zolmitriptan Mouth dissolving tablets were prepared by direct compression method and different concentration super disintegrants like croscarmellose sodium, polyplasdone XL and Explotab were used in mouth dissolving tablets. A total of 9 formulations were prepared and evaluated for various pre and post compression parameters like angle of repose, bulk density, tapped density, carr’s index, hausner’s ratio, weight variation, hardness, friability, thickness, wetting time, drug content, in vitro disintegration time, in vitro drug release. The in vitro disintegration time of the optimised formulation (F3) of Zolmitriptan was found to be 28 sec. Release rate of drug was 99.65% within 12 hours. FTIR studies showed good compatibility between drug and excipients.

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