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ANTIDIABETIC PROPERTIES OF METHANOLIC EXTRACTS OF CARISSA CARANDAS L. FRUITS IN ALLOXAN-INDUCED DIABETIC MICE
Shahanaz Khatun* and Shirin Sultana
In many Asian countries such as India, Bangladesh, Myanmar and Malaysia, Carissa carandas L., is commonly used as healing plant to treat diabetes. The purpose of the presents study was to assess the therapy effect of Carissa carandas L., fruit extract on glucose level, total cholesterol, triglyceride, LDL-cholesterol, and HDL-cholesterol in blood serum of diabetic animals. Hyperglycemia was induced by an injection of alloxan monohydrate 150 mg/kg (i.p.). After 72 hr, the mice having Blood Glucose Level (BGL) greater than 13.9. mmol/dL were selected for the investigation. BGL was monitored after 1, 5, 10, 15 and 21 days and compared with Glibenclamide (5 mg/kg). A Methyl alcohol extract of Carissa carandas L., fruit was daily administered orally by gavages to mice in doses of 50 and 100 mgkg-1 b.w. for 21 days to evaluate the antidiabetic and antihyperlipidemic effects on normal and alloxan-induced diabetic mice. Levels of blood serum glucose, total cholesterol, triglyceride and LDL-cholesterol decreased in alloxan-induced diabetic mice after treatment with 50 and 100 mgkg-1 b.w. methyl alcohol fruit extract of Carissa carandas L., for 21 days. The study validates scientifically the widely claimed use of Carissa carandas L., fruit as an ethnomedicine to treat diabetes mellitus.[Full Text Article]