WORLD JOURNAL OF ADVANCE
HEALTHCARE RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Review Journal for Medical Science and Pharma Professionals

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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ISSN 2457-0400

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Indexing

Abstract

A COMPARATIVE STUDY ON THE EFFICACY OF AMBROXOL HYDROCHLORIDE AND AMBROXOL HYDROCHLORIDE WITH N-ACETYL CYSTEINE IN THE TREATMENT OF BRONCHOPNEUMONIA IN CHILDREN AND THEIR INFLUENCE ON PROGNOSIS

*Kunchala Naresh, Polepaka Priyanka, Bankerlang Marbaniang, T. Sanjay Chary, Dr. Aravinda Reddy P.

ABSTRACT

Background: About 2.5 million people died from bronchopneumonia in 2019. Almost a third of all victims were children younger than 5 years, it is the leading cause of death for children under 5 years, bronchopneumonia is an infection of the tiny air sacs of the lungs, called alveoli. We conducted a comparative study to evaluate the efficacy of ambroxol hcl and combination of N-acetylcysteine with ambroxol hcl for the treatment of bronchopneumonia in children. Aim: The main objective of the study is to compare the efficacy of Ambroxol Hcl and combination of N-acetyl cysteine with Ambroxol Hcl by comparing the symptoms disappearance time, adverse reactions and quality of life between the two groups. Materials and Methods: A comparative observational study was Conducted in pediatrics department in a tertiary-care hospital. The data was collected from the in-patient department after considering all the inclusion and exclusion criteria for a period of 6 months and a total of 116 children with bronchopneumonia were analyzed with data collection form and SF-36 scoring questionnaire and physical examination. statistical tools like chi-square test were applied to the data by using spas version -22, IBM software. Results: A total of 116 children with bronchopneumonia were enrolled in this study. Among them 60 children were treated with N-acetyl cysteine and Ambroxol HCl and comprised as group A, and 56 children were treated with Ambroxol HCL and comprised as group-B. children physical signs and adverse reactions to the treatment were recorded and observed, and symptoms disappearance time was recorded and the quality of life after the treatment was investigated. There was no significant difference in clinical data between two groups (p>0.05).The effective rate in the group A (93.3%) was significantly higher than that in the group B (85.7%). The disappearance time of symptoms was significantly shorter in group A than in group B. (pk 0.05). The hospitalization time of children in group A was shorter than that in group B. The incidence of adverse reactions in group A was significantly lower than that in group B. Conclusion: By comparing the symptom disappearance time and adverse reaction between the two group, the total efficacy of combination of N-acetyl cysteine with Ambroxol HCL in the treatment of bronchopneumonia in children was higher than the children treated with only Ambroxol HCL. SF-36 scoring system concluded better quality of life in children receiving combination of Ambroxol HCL and N-acetyl cysteine compared to the children receiving Ambroxol HCL only.

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